Endocrine Abstracts

Hyperthyroid patients show an impaired response or even resistance to digoxin treatment.Objectives: 1. Are there any differences in the pharmacokinetics of a single oral dose of digoxin between hyperthyroid and euthyroid patients? 2. Does simultaneous administration of digoxin and methimazole or digoxin and acebutolol affect the pharmacokinetics of a single oral dose of dogoxin? 3. Does methimazole-induced euthyroidism change the pharmacokinetics of a si...